Cardiovascular physician Professor Eugene Braunwald once commented on heart failure: "It is the last battleground of heart disease." It is important to see the medical significance of heart failure. At present, the number of heart failure patients worldwide has reached 23 million. In the global population over 70 years old, one in ten people suffer from heart failure. According to Cong Hongliang, director of the Department of Cardiology of Tianjin Chest Hospital, "As the ultimate outcome of multiple cardiovascular diseases, heart failure is the only cardiovascular disease with increasing prevalence, morbidity and mortality. †In the medical world, the three common methods for diagnosing heart failure are: chest radiography, cardiac ultrasound, and BNP or NT-proBNP. Dr. Lepu's heart failure management system, which is known as "the world's first heart failure management tool," is such a product that can detect NT-proBNP. So what is this so-called "third diagnostic method"? NT-proBNP, the "gold standard" for the diagnosis of heart failure The author has reviewed some information and tried to explain it in a simple language: We all know that the heart is constantly beating and pumping blood for the various organs of our body. When the heart muscle stretches, the heart's volume load increases, and the heart releases a chemical. After a series of metabolism, it becomes brain natriuretic peptide (BNP) or N-terminal brain natriuretic peptide (N- Terminal fragment BNP, NT-proBNP). The difference between the two is that the latter has a longer half-life (up to 60-120 min) and is more stable (the blood specimen can be placed at room temperature for 72 h), which is easier to detect. The level of NT-proBNP in normal human serum/plasma is extremely low, and the elevated NT-proBNP level in patients has a good diagnostic value. However, NT-proBNP is not the only marker of heart failure. Obesity and renal insufficiency, thyroid function, and application of estrogen may affect the level of NT-proBNP, so the academic community has slightly different views on the critical value. In an article published in the Chinese Journal of Hypertension, Chen Luyuan and Wu Straw pointed out that regardless of whether the patient is obese with or without renal dysfunction, gender differences, and whether there is diabetes, NT-proBNP uses a uniform cut-off value in the elimination of heart failure. Professor Pan Baishen, director of the Department of Clinical Laboratory of Zhongshan Hospital affiliated to Fudan University, said at the China International Heart Failure Conference this year: "Although the clinical cutoff value of NT-proBNP for Chinese population is still to be further studied, the current diagnostic cutoff value is still relatively high. Good diagnostic reference."
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