The first nationally successful 3D printing to achieve maternal and child liver transplant surgery successfully completed in Shanghai

Release date: 2015-11-23

After 3D printing, the hepatobiliary pancreas and the corresponding lesions are presented in front of the doctor in a 1:1 "physical" form.

Recently, Professor Peng Zhihai, the director of the General Surgery Center of Shanghai First People's Hospital, used 3D printing technology to successfully print a liver simulation stereo model of donors, guiding doctors to complete a complicated small-volume graft in situ more quickly and accurately. Liver transplantation, the child and the mother's liver are taken in half, spliced ​​together, the mother and child are safe.

It is understood that the use of 3D printing technology for liver transplantation is the first in the world, and the small-sized graft original liver transplantation for children is also the first case in Shanghai.

The child is too heavy, the mother donated enough liver

Xiao Zhihao from Guizhou is 10 years old and came to a hospital in Shanghai for suffering from congenital autoimmune cirrhosis with portal hypertension. After examination, Xiao Zhihao's liver function is seriously deficient and requires live liver transplantation. After matching, Xiao Zhihao's mother meets the transplant requirements. However, after further analyzing the patient's original image data into the three-dimensional visualization system of the abdominal medical image, Professor Zhi Lin, the chief surgeon of Zhihao and the director of the Department of Hepatobiliary and Pancreatic Surgery of the General Hospital of the First Hospital, found a difficult problem.

"In liver transplantation, there is a concept of receptor-to-receptor weight ratio, that is, the ratio between the donor's liver weight and the recipient's body weight, which is generally required to be greater than or equal to 1%." Zhong Lin said, "Zhihao's mother The right half of the liver weighs about 600 grams, and the left half leaves about 300 grams. If the right half of the liver is donated to Zhihao, the remaining liver is too small, which may cause the mother to be in danger. If the liver is donated in the left half For Zhihao, then according to Zhihao’s own weight of 44 kilograms, the weight ratio of recipients is only 0.66%, which is less than 1% of the requirement.” Children are prone to small liver syndrome, and graft loss will occur after operation. Functional situation. "Zhong Lin said.

Printed donation liver model for the precise positioning of the splicing in the face of further deterioration of the patient's condition, the expert team decided to decide on the patient's cutting-edge technology in liver transplantation technology - small-volume graft orthotopic liver transplantation, ie resection of the child left Hemi-hepatic, retaining the right half of the liver, using the mother's left hepatic liver and the child's left hepatic vein, left portal vein and left hepatic artery, and left bile duct anastomosis, which can ensure that both the donor and the recipient can maintain the organism Normal liver function.

"Surgery has extremely high requirements for accuracy. There should be no more and less resection of the donor. More donors have the risk of liver failure and less survival after transplantation." Zhong Lin analysis, the size of the liver needs to be performed before surgery. , shape, blood vessels, bile ducts for precise planning, a slight error may lead to surgery failure.

To this end, he thought of 3D printing technology, which can make the hepatobiliary pancreas and corresponding lesions appear in front of the doctor in a 1:1 "physical" form, and accurately estimate the extent of the lesion and the three-dimensional tissue of the adjacent organs before surgery. Spatial relationship, detailed surgical planning, tailoring the best donor liver for patients, and achieving accurate and individualized living transplant surgery.

After careful analysis and calculation, the expert team determined to remove 307 grams of liver from Zhihao mother. During hepatectomy, the expert brings the model into the operating room and compares it with the intraoperative real-time surgery. By adjusting the 3D printed model and placing it in the best anatomical position, it provides intuitive real-time navigation for key surgical steps, by pinpointing the lesion, The blood vessels guide the engagement of important vessels in real time, which improves the accuracy of surgery and effectively reduces the risk of surgery.

The operation was successful, and Xiao Zhihao’s mother was discharged two weeks after the operation. Xiao Zhihao’s current situation is also stable. Deputy Director Wang Zhaowen, who is in charge of pediatric liver transplantation, said that the healthy liver transplanted into the child's body will proliferate to 60% of the standard liver volume after one month, and the patient's self-hardening liver will gradually shrink.

Source: 澎湃News

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