Japanese research uses 3D printing technology to produce complex tissues such as blood vessels July 27, 2016 Source: Medical Valley At present, in the field of regenerative medicine, many research institutions in Japan are studying the use of 3D printing technology to produce complex tissues such as blood vessels. Saga University prints a cell population cultivated from iPS cells (human induced pluripotent stem cells) into a tubular structure to form blood vessels. Kyoto University used 3D printing technology to make a nerve-like tubular tissue and transplant it into the experimental mouse to achieve nerve regeneration. The Japanese government predicts that by 2020, iPS cells will be used to treat diseases such as heart disease, and it is in the process of mastering the artificial three-dimensional tissue transplantation technology similar to the shape of human tissues. iPS cells are not only used to treat difficult conditions in the eye, but may also be used to treat heart failure and spinal cord injury in the future. Tubular and pocket-like tissue structures often require the use of many cells when culturing long vessels and stereoscopic viscera for transplantation therapy. The research team believes that since the principle of 3D printing technology is to print a layered layer of resin material, if you use cells instead of resin, you can print a three-dimensional structure. Saga University professor Morita Miki's research team cultured human iPS cells into a group of cells that can develop into blood vessels, and stratified the cells in a multi-row microneedle array of micro-pedestals, and finally printed a length of 2 cm. 5 mm tubular structure. The tubular structure cells were removed from the fine needle and the culture medium was used internally. Differentiation into different kinds of cells after a few days will form a cell layer on the inner wall, eventually forming blood vessels. Vascular transplantation experiments will be carried out on pigs in the future. The study used the "Bio3D Printer" developed by Cyfuse, a startup founded by Kyushu University, in collaboration with Silicon Valley Industries. There is currently a method of treating myocardial infarction in which the patient's other blood vessels are removed to replace the blocked blood vessels. However, this method imposes a great burden on the human body, and the use of artificial blood vessels tends to cause siltation again, so that blood vessels made of iPS cells are expected to be high. The research team of Kyoto University Associate Professor Chikusuke Ryosuke used a cell that can differentiate into tissues such as skin to make a tubular structure 8 mm long and 3 mm in diameter. It was transplanted into the wound of the experimental mouse with the part of the nerve removed. After 8 weeks, the nerve connection was generated in the tube, and the mouse resumed walking ability. It can be seen that the tubular structure can cultivate cells that grow into nerves and promote nerve regeneration. The technology is put into clinical research after 3 years of planning. Solid Drink,Organic Solid Drink,Organic Solid Grass Powder,Organic Solid Grass Juice Powder Hengshui Shanzhi Health Drink Co., Ltd , https://www.grasspowder-sz.com