Drug-loaded soluble fiber or protects the body from HIV infection

Release date: 2014-08-13

Perhaps in the near future, people who insert a drug-containing woven fabric into the body before sexual activity can be protected from HIV infection; recently, in a research paper published in the international journal Antimicrobial Agents and Chemotherapy, Researchers at the University of Washington have discovered a rapid path to transport topical drugs that can protect women from HIV by placing the drug in a filamentous fiber that is in contact with water. It dissolves quickly and releases high doses of the drug.

Researcher Cameron Ball said the approach may provide women with an efficient way to protect them from HIV infection. Previously, researchers found that electrospun cloth can dissolve and release drugs quickly. The research in this paper is based on previous research. Currently, in the United States, individuals who are at risk of HIV infection often take oral drugs to prevent infection, but with gel or The topical medication in the form of a film has only just begun.

The effectiveness of anti-HIV topical drugs depends on their higher doses and faster release rates. Researchers have been able to find high-dose drug-loaded materials. The researchers developed a material called electrospinning. A soft fiber that helps dissolve the polymer and the drug molecule maraviroc that carries the polymer. The current drug maraviroc is a drug used to treat HIV-infected people.

The syrupy soft fiber material can then be charged by a high pressure generator and passed through a syringe, and the charge on the surface of the object promotes the formation of shaped elongated strips of syrup-like soft fibers in the syringe; anti-HIV drugs, For example, maraviroc takes a while to dissolve, so the researchers examined several different components of the fiber and observed which one can be released at the maximum concentration in the human body. Because of the large surface area of ​​the charged light, the researchers A drug content of nearly 30% can be charged therein, and the volume of the drug is only 3% under the action of the topical gel.

By adjusting the composition of the fiber, regardless of the amount of the drug, the researchers can dissolve the drug within 6 minutes; the researcher Woodrow said, we can wrap the soft and soluble wire and then make the vaginal ring. Structure, so that it can be implanted in women to help fight HIV infection; this study may help researchers develop a drug fiber that prevents HIV infection, and the research is funded by NIH.

Source: Bio Valley

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