A new article in the journal Nature: Why does acupuncture lower blood pressure?

A new article in the journal Nature: Why does acupuncture lower blood pressure?

October 31, 2016 Source: Science Horizon

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One in every three adults in the world has high blood pressure. Hypertension is one of the major risk factors for severe stroke, myocardial infarction (MI), heart failure, aneurysms (such as aortic aneurysm) and peripheral arterial disease, and is one of the causes of chronic kidney disease. Even a mild increase in arterial blood pressure can shorten life expectancy.

Researchers at the Susan Samueli Center for Integrated Medical Research at the University of California School of Medicine have used modern medicine and biomolecular methods to reveal that electroacupuncture reduces blood pressure by affecting enkephalin in the ventrolateral medulla of the rat brain. Synthetic to achieve. So what is the specific research design and results?

Cold-induced hypertension (CIH) rats were randomly divided into EA (electric acupuncture treatment group), sham operation group and untreated hypertension group. Repeated electroacupuncture or sham surgery was performed at Zusanli and Shangjuxuan points, or only after 30 weeks in the cold room, and given 30 minutes of treatment twice a week for another five weeks. In the 11th week. Blood pressure (BP) of all groups of rats was evaluated weekly using tail sleeve manometry. Within 24 or 72 hours after five weeks of treatment, the rats were decapitated or microinjected to examine the effects of proenkephalin mRNA levels and delta-opioid receptors in the ventrolateral medulla of the rostral ventricle, respectively.

Now let us see how the results of electroacupuncture treatment of hypertension are?

It can be seen that the cold-induced hypertensive rat model increases systolic blood pressure after four weeks and induces persistent hypertension for six weeks. The blood pressure and heart rate of the rats in the hypertension and sham-operated groups remained elevated until 11 weeks. In contrast, the EA (Electric Acupuncture) group maintained a low value during EA treatment. Moreover, the blood pressure of CIH rats treated with electroacupuncture was still significantly lower than that of sham-operated EA within three days after electroacupuncture treatment. ^, *, and # respectively indicate that the electroacupuncture was P < 0.05 compared with the sham-operated EA, CIH, and normal blood pressure controls.

The data showed that the electroencephalogram stimulated the Zusanli and Shangjuxuan acupoints, and the content of enkephalin precursors in the brain tissue, especially the ventrolateral medulla of the rostral medulla, was significantly increased by RT-PCR.

In order to further verify that the antihypertensive effect of electroacupuncture is achieved by regulating the enkephalin of the ventrolateral medulla of the brain. The researchers injected the δ-opioid receptor antagonist ICI 174,864 and the agonist DADLE by microinjection in the ventrolateral medulla of the rostral medulla. The results showed that the antagonist "closed" the antihypertensive effect of electroacupuncture and the blood pressure rose again. The agonist causes the blood pressure to drop again.

Science is about rigor, so is microinjection really injected into the ventral region of the medullary medulla of the brain? Then we analyze the brain slices and look them carefully under the microscope. As a result, there is no doubt that all antagonists and agonists are injected into the ventrolateral medulla of the rat brain, which has long been studied by scientists. It is considered to be the central control region of the cardiovascular system.

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PH0.9 ~ 1.8.
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