Release date: 2015-02-25 Recently, researchers from Baylor College of Medicine published a new study in the international journal nature communication. They found that co-activation of nuclear exogenous receptor CAR and β catenin can induce proliferation of differentiated liver cells in mice, leading to cell proliferation. Out of control, liver cancer occurs. The results of this study demonstrate that the mouse model of liver cancer has a direct relationship with human HCC, so the use of liver cancer mouse model for drug development and basic research is of greater significance. The researchers mentioned in the article that abnormal expression of β catenin can promote the development of human hepatocarcinoma, but only β catenin activation is not enough to induce cancer in the liver of mice. They found that acute activation of beta catenin and nuclear exogenous CAR can induce the proliferation of differentiated liver cells, which are normally restricted and closely linked in the CAR-dependent tumors induced by phenobarbital. Almost all of the activation of beta catenin occurs. The researchers confirmed that complete activation of β catenin in the liver can induce cell senescence and growth arrest. When the CAR is activated simultaneously, although the liver still has normal function, cell senescence and growth arrest disappear, and cell uncontrolled proliferation and hepatomegaly appear. And fast lethality. CAR activation and partial activation of beta catenin are able to induce tumorigenesis, and these tumor cells have similar conserved gene expression with beta catenin-positive human HCC. Taken together, the results of this paper indicate that co-activation of CAR and β catenin can induce liver cancer, and define the direct relationship between mouse model of liver cancer and human HCC. Source: Bio Valley The egg sitter seat cushion use modern innovation material of Gel. Not like foam or polyester cushion. The egg sitter seat cushion have the feature with cooling, undeformed, easy washable. Honeycombo design to keep the air circulation to stay cool, provide you with optimal lumbar support and comfort. We are China professional manufacturer, we made the products from 2019 year. Our products quality is nice, our products have CE,Rohs,BSCI certificated. If you are interested in it, welcome to contact us. egg sitter seat cushion, egg sitter support cushion, gel seat cushion, cooling seat cushion,gel support cushion Ningbo Prestigeplus Commodity Co.,Ltd , https://www.prestigemedics.com
Study human HCC with hepatoma mouse model, why?
Recently, researchers from Baylor College of Medicine published a new study in the international journal nature communication. They found that co-activation of nuclear exogenous receptor CAR and β catenin can induce proliferation of differentiated liver cells in mice, leading to cell proliferation. Out of control, liver cancer occurs. The results of this study demonstrate that the mouse model of liver cancer has a direct relationship with human HCC, so the use of liver cancer mouse model for drug development and basic research is of greater significance.