The mechanism of antiviral infection regulation reveals that aspirin can inhibit cell "gate" cGAS activation

Currently, more than 1.5 million viruses worldwide cause disease. The cyclic adenylate synthase (cGAS), which is hailed as the cell "gate", is a key target for antiviral infection and treatment of major diseases, and is also a hotspot for global scientific research. On February 22nd, the international authoritative academic journal "Cell" published online research results of Dr. Li Tao from the Military Medical Research Institute of the Academy of Military Sciences and Zhang Xuemin, a member of the Chinese Academy of Sciences, who not only revealed the regulation mechanism of cGAS against viral infection, but also found Aspirin inhibits cGAS activation by acetylation. But the R&D team also stressed that whether aspirin can treat systemic lupus erythematosus and other related diseases requires further research.

When a virus invades an organism, it releases its own nucleic acid material into the cells of the organism. In this process, cGAS is equivalent to a guardian that can detect virus intrusions. In addition, abnormal activation of cGAS is also an important cause of autoimmune diseases such as systemic lupus erythematosus.

"Inhibition of cGAS can be used to treat autoimmune diseases, and may also control uncontrolled immune responses caused by viruses. Increasing the activity of cGAS can promote antiviral infection and tumor immunotherapy. Therefore, to find effective regulation of cGAS activity. The means and explore its regulatory mechanisms are essential for the fight against viral infections, the prevention and control of major infectious diseases and the treatment of autoimmune diseases," Li Tao said. To this end, the team started with the research mechanism and launched joint research. They found that acetylation modification is a key molecular event that controls cGAS activity. "Acetylation is the addition of a small molecule to a suitable target to regulate cGAS activity."

On this basis, the researchers conducted biochemical verification by specific site acetylation antibodies, and finally found that aspirin can force cGAS acetylation and inhibit cGAS activity. They believe that these efforts not only reveal new targets and molecular mechanisms that aspirin acts on the human body, but also provide potential treatments for this type of autoimmune disease.

Zhang Xuemin said that the work reveals the regulation of the regulation of viral infections, so that when responding to major epidemics, it not only has the means to control known virus infections, but also has the ability to respond to unknown virus infections. Next, the research team will conduct more research on the optimization of pharmaceutical dosage forms and medications. (Reporter Wang Yuyu correspondent Zhuang Yingna Du Fei)

Source: Health News

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