How does the new hormone asprosin exert potential disease effects? April 20, 2016 Source: Bio Valley Neonatal Progeroid Syndrome (NPS) is a rare hereditary disorder that accumulates fat in the body of the patient. Until now, scientists are not aware of the cause of the disease. Recently, it was published in the international community. In a research paper on the magazine Cell , researchers from Baylor College of Medicine revealed a major mechanism for the disease, and related research will have a major impact on improving the health of neonatal premature aging and type 2 diabetes patients. As early as 2013, researchers discovered this rare disease, when researchers conducted genome-wide and exome sequencing to find the cause, and the researcher Chopra has long been committed to the study of energy metabolism disorders. Researchers have discovered specific genetic mutations that cause premature aging in newborns. However, it is not clear how these mutations cause the disease. Later, the researchers conducted related studies in the laboratory and found that these mutations inhibited. The patient's body produces an unknown hormone, and the hormone called asprosin seems to be produced by fat. When it circulates to the liver, it directs the liver to release glucose into the blood, while NPS patients with abnormally low levels of asprosin in the body usually The above process cannot be completed, and the body usually exhibits lower levels of hypoglycemia and insulin. Based on this level of information, the researchers decided to develop an antibody against parsporin, which is higher than the level of aspirin in individuals with normal and high levels of insulin. Special antibodies are used to neutralize aspirins, a process known as immunoisolation, which may help reduce the level of glucose released in the liver of a patient, thereby promoting the release of lesser amounts of insulin by pancreatic cells. To test this theory, the researchers used newly developed antibodies to treat diabetic mice. It was found that a single dose of antibody can regulate the insulin levels in the mouse to normal levels. If the mice are treated for a long time, small The insulin resistance of the mouse is completely restored. Researcher Chopra said that the study explained the whole process for us. We started with this rare genetic disorder (premature neonatal premature aging) and then used patient information to discover a new hormone that can be found. Can be targeted to treat diseases affecting many people; if diabetics respond to anti-asprosin antibodies in the same way as diabetic mice, then this study is likely to help scientists develop a new type of diabetes therapy; One of the highlights is that it can help scientists to clearly analyze the mechanisms of rare genetic disorders in humans. Education Microscope ,Educational Microscope,Student Microscope,Teaching Microscope Ningbo ProWay Optics & Electronics Co., Ltd. , https://www.proway-microtech.com