Release date: 2015-07-16 Recently, in order to rescue the people injured in the dust explosion accident in Taiwan on June 27, Sheng Zhiyong, Wang Zhengguo, Xia Zhaofan, and Fu Xiaobing, four academicians of the Chinese Academy of Engineering, collected medical supplies such as allogeneic skin and nano silver accessories from medical institutions, and received many urgently needed supplies. People pay attention. The accident killed 2 people and injured 495. Most patients with burns need skin during debridement. However, there is a limited amount of such skin in Taiwan, which cannot meet the needs of dressing and skin grafting. Artificial skin has also become a highly valued resource when four academicians recruited allogeneic skins. However, relevant experts in the interview with the "Journal of the Chinese Academy of Sciences" revealed that China's artificial skin has not been able to "show the talents" in the case of major burns and scalds, in case of unexpected situations, artificial skin is difficult to meet the needs of large-scale burns and burns, industrialization The "pain" of artificial skin itself. Skin reserve is difficult to respond to After the dust explosion, Guo Yueming, general manager of Huayi Cell Tissue Engineering Co., Ltd. (hereinafter referred to as Huayi Company) received a phone call from the Taiwan Affairs Office of the People's Government of Jiangsu Province on donating skin resources. "At present, we have prepared artificial skin and debridement disinfection products worth 4 million yuan, and are waiting for the donation notice." He told the reporter of the Chinese Journal of Science. On August 2 last year, a large aluminum dust explosion accident occurred in a company in Kunshan, Jiangsu Province, killing 75 people and injuring 185 people. Huayi Company donated 60,000 square centimeters of artificial skin to the hospital participating in the treatment within 2 hours of the accident. "In an emergency, we can produce 80,000 to 100,000 square centimeters of artificial skin every day," Guo Yueming said. An adult has a skin area of ​​about 10,000 square centimeters. In the dust explosion in Kunshan, due to limited production capacity, the 60,000 square centimeters of skin donated can only be used in key parts such as the injured person's face. "There are many patients." Can't use it." At present, in addition to temporary production, the company and Fudan University, the Third Military Medical University, Shanghai Jiaotong University have jointly established an artificial skin library, currently storing 5 million square centimeters of artificial skin, worth about 900 million yuan. "In order to respond safely to large groups of burns, the storage of artificial skin needs to be between 50 million and 100 million square centimeters, and for any company, this means an unbearable amount of money." Guo Yueming said Domestic artificial skin storage is still far from this level. It is understood that in China, tens of millions of patients need to be treated every year due to burns, mechanical damage or chronic skin ulcers. Due to the lack of skin resources, nearly 100,000 patients with severe skin defects die due to lack of timely and effective treatment. Sheng Zhiyong called for emergency donations and expert rescue mechanisms for mass incidents in the field of burning and trauma. Start late but catch up fast For a long time, people can only transplant or repair severely burned skin defects by cutting the skin of the normal part of the patient's legs and back, leaving a new trauma to the patient, and the source is limited. After the 1980s, foreign scientists developed a variety of artificial dermis, which can induce patients to reconstruct the dermis itself. "China's artificial skin research started 10 to 15 years later than foreign countries." Ma Li, a professor of tissue repair and regenerative medical polymer materials at Zhejiang University, said in an interview with the Journal of Chinese Sciences. Marley told reporters that some of the "artificial skin" developed in China is actually a wound dressing. In the early stage of treatment, the wound can be covered to protect against dehydration and infection. The "artificial skin" technology that can be used for post-repair and regeneration is relatively higher. In terms of tissue engineering skin, in February 2012, China's first stem cell artificial skin product industrialization base was built in Xi'an, becoming the earliest artificial skin in China. Jin Yan, director of the technology and director of the Tissue Engineering Research and Development Center of the Fourth Military Medical University, said during the interview that the technology can be cultivated by extracting human stem cells to produce a highly similar human skin for transplantation, treatment and improvement of human skin. . In addition, many researchers have now used collagen materials, chitosan and other materials to produce cell-free skin regeneration products using biomaterial science, polymer science, and recombinant materials. "This artificial skin avoids problems such as cell source and immunogenicity, low cost, controllable quality, and easy production, storage and transportation." Marley said that the new in situ induced skin regeneration material developed by its research group has Enter the stage of clinical trial approval. In addition, Marxism said that the development of artificial skin with skin appendages such as sweat glands and hair follicles and skin's own functions is also a hot spot in international research. Industrialization is really "pain" Despite the high hopes of artificial skin, the reporter learned that nowadays, in the treatment of burn patients, most of the hospitals use autologous skin and allogeneic skin for covering and transplanting. According to Marxism-Lenin, there is still a gap in the industrialization of artificial skin in China compared with the international level. “Foreign artificial skin started early, and the capital market was relatively active at that time. The national investment and market input went hand in hand, which promoted industrial development.†However, the development of China's skin regenerative products is still driven by the strength of the state. The early development of new technologies is mainly based on research institutes and universities. Marxism hopes that the state can increase the efforts to bridge the gap between enterprises and research institutes, reduce the investment concerns of enterprises, and introduce more market elements to promote the transfer of technology. However, for artificial skin companies, market problems have become as important as production and technology. Guo Yueming expressed the feeling that although the annual output can reach 23 million square centimeters in the future, in the process of expanding the market, they also need to face problems such as low awareness of new technologies and linkages among doctors. Source: Science Network JIANGSU CLS TECHNOLOGY CORP.LTD , https://www.js-cls.com