Accurate DNA Drug Delivery System: 3DNA Technology Secures Evidence November 16, 2017 Source: Sina Pharmaceutical As we all know, DNA is the carrier of life genetic information. DNA strands can recognize each other in a base-complementary manner. This also gives some unique characteristics of this macromolecule. A biotechnology company called Genisphere in the United States hopes to use this property of DNA to develop a new nano drug delivery system. Recently, the company announced the success of a non-GLP animal safety experiment, which also laid a good foundation for scientists to further promote the development of this DNA drug delivery system. Genisphere and the world-renowned CRO company Calvert collaborated on this research. The researchers evaluated the effects of dose climbing and repeated injections of DNA nanocarriers in Sprague Dawley rats. This result showed that the rats did not show significant side effects after repeated administration to the rats at the maximum dose by intravenous injection. Dr. Vincent Meador, a world-renowned toxicologist, said that the results have proved to a certain extent to Genisphere's corporate partners that the company's unique 3DNA technology is safe. In the future, the company plans to conduct more research to further prove the safety of this drug delivery system. According to Genisphere CSO Bob Getts, this study has initially demonstrated the good biocompatibility of 3DNA technology. In recent years, nano drug-loading systems have gradually become the new darling of the pharmaceutical industry. In addition to the past liposome drug-loading systems, scientists have developed a variety of new drug-loading systems, including micellar drug delivery systems and nanogold particle drug delivery systems, to reduce the toxic side effects and enhance drug efficacy. In any case, Genisphere's choice of DNA drug delivery system is one of the most "radical" choices. The company's unique 3DNA platform technology utilizes DNA base pairing to form a double-layered DNA spherical structure. The internal DNA core helps stabilize the drug delivery system morphology, and the DNA single strand exposed by the external DNA layer can be used to bind small molecule chemotherapy drugs, peptides and the like. At the same time, researchers are able to label specific antibodies on this drug delivery system to enhance the targeted delivery capabilities of drug-loaded systems. One of the advantages of using DNA to construct a drug-loading system is that the base pairing of DNA ensures that the drug-loading system formed is stable and controllable. Since the number of DNA molecules that ultimately form drug-loaded particles can be accurately calculated, scientists can accurately calculate the drug loading of the 3DNA system, which will help to accurately deliver drugs in the future. (Sina Pharmaceutical Compilation / Sheep Pharmacist) Article reference source: Https:// Https://genisphere.com/ Cool Tech Fat Freezing Machine,360 Criolipolisis Double Chin Removal,Fat Freezing Slimming Machine Xi'an Double H Health Technology Co., Ltd , https://www.dhextract.com
