Immune Suppressant Tacrolimus Anti-Inflammatory Fk-506 104987-11-3

Model NO.: 3000
CAS: 850-52-2
Mf: C21h26o2
MW: 310.43
Einecs: 212-703-1
Trademark: YIJING
Transport Package: as Your Request
Specification: 25kg/drum
Origin: China
Model NO.: 3000
CAS: 850-52-2
Mf: C21h26o2
MW: 310.43
Einecs: 212-703-1
Trademark: YIJING
Transport Package: as Your Request
Specification: 25kg/drum
Origin: China
Tacrolimus Powder Description:
1.Tacrolimus is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.
 
2.A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
 
3.Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo.
 
4.Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
 
5.Tacrolimus is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). This medicine may be used with steroids, azathioprine, basiliximab, or mycophenolate mofetil. Tacrolimus belongs to a group of medicines known as immunosuppressive agents.

6.Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.
 
Tacrolimus Powder Mechanism of action:
1.The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12.
 
2.A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines.
 
3.Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-, all of which are involved in the early stages of T-cell activation. Additionally, tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to downregulate the expression of FceRI on Langerhans cells.
 
Tacrolimus Powder Usages:
1.Tacroz Forte Ointment (Tacrolimus) is used to treat atopic dermatitis (more commonly known as eczema). It is a topical medication which is normally prescribed for patients who have not responded successfully to other eczema medication.
 
2.The ointment is a type of topical calcineurin inhibitor (TCIs) that works by weakening the patient`s immune system, which as a consequence directly reduces the severity of eczema and its symptoms. It should not be used by patients who have any kind of weak immune system.

Dermatological use:
1.As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side-effects.
 
2.It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids[citation needed]. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face

Tacrolimus Powder Dosage and Administration:
Tacroz Forte Ointment (Tacrolimus) is applied directly to the affected skin. Patients are normally advised to apply the ointment twice a day for a period of approximately 6 weeks in length. If no changes or improvements to your condition occur after this period, consult your physician to discuss how best to go forward.

COA:
Tests Specifications Results
Description A white or off-white crystalline powder Conform
Identification 1. IR (USP <197K>) Conform

 
2. HPLC retention times Conform
Water 
(USP <921> Method I)
1.6 ~ 3.0% 2.1%
Residue on ignition 
(USP <281>)
£ 0.2% 0.08%
Heavy metals 
(USP <231> II)
£ 20 ppm < 20 ppm
Related substances (In-house HPLC method) Ascomycin £ 0.8% 0.064%
Residual solvents 
(In-house method)
Acetone £ 2000 ppm Not detected
Assay (on anhydrous basis) 98.0% ~ 102.0% 100.0%
Conclusion: Complied with In-House standard
Tacrolimus Powder Description:
1.Tacrolimus is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.
 
2.A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
 
3.Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo.
 
4.Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
 
5.Tacrolimus is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). This medicine may be used with steroids, azathioprine, basiliximab, or mycophenolate mofetil. Tacrolimus belongs to a group of medicines known as immunosuppressive agents.

6.Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.
 
Tacrolimus Powder Mechanism of action:
1.The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12.
 
2.A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines.
 
3.Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-, all of which are involved in the early stages of T-cell activation. Additionally, tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to downregulate the expression of FceRI on Langerhans cells.
 
Tacrolimus Powder Usages:
1.Tacroz Forte Ointment (Tacrolimus) is used to treat atopic dermatitis (more commonly known as eczema). It is a topical medication which is normally prescribed for patients who have not responded successfully to other eczema medication.
 
2.The ointment is a type of topical calcineurin inhibitor (TCIs) that works by weakening the patient`s immune system, which as a consequence directly reduces the severity of eczema and its symptoms. It should not be used by patients who have any kind of weak immune system.

Dermatological use:
1.As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side-effects.
 
2.It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids[citation needed]. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face

Tacrolimus Powder Dosage and Administration:
Tacroz Forte Ointment (Tacrolimus) is applied directly to the affected skin. Patients are normally advised to apply the ointment twice a day for a period of approximately 6 weeks in length. If no changes or improvements to your condition occur after this period, consult your physician to discuss how best to go forward.

COA:
Tests Specifications Results
Description A white or off-white crystalline powder Conform
Identification 1. IR (USP <197K>) Conform

 
2. HPLC retention times Conform
Water 
(USP <921> Method I)
1.6 ~ 3.0% 2.1%
Residue on ignition 
(USP <281>)
£ 0.2% 0.08%
Heavy metals 
(USP <231> II)
£ 20 ppm < 20 ppm
Related substances (In-house HPLC method) Ascomycin £ 0.8% 0.064%
Residual solvents 
(In-house method)
Acetone £ 2000 ppm Not detected
Assay (on anhydrous basis) 98.0% ~ 102.0% 100.0%
Conclusion: Complied with In-House standard

Antiviral & Anti-cancer

Antiviral:

Antiviral drugs are a class of medication used specifically for treating viral infections. Like antibiotics and broad-spectrum antibiotics for bacteria, most antivirals are used for specific viral infections, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit their development.


Antiviral drugs are one class of antimicrobials, a larger group which also includes antibiotic (also termed antibacterial), antifungal and antiparasitic drugs, or antiviral drugs based on monoclonal antibodies. Most antivirals are considered relatively harmless to the host, and therefore can be used to treat infections. They should be distinguished from viricides, which are not medication but deactivate or destroy virus particles, either inside or outside the body. Antivirals also can be found in essential oils of some herbs, such as eucalyptus oil and its constituents.Related Products:antiviral drugs,anti-cancer drugs.


Anti-cancer:

Anticancer, or Antineoplastic, drugs are used to treat malignancies, or cancerous growths. Drug therapy may be used alone, or in combination with other treatments such as surgery or radiation therapy.

For the treatment :

Anal cancer

Bladder cancer

Bone cancer

Breast cancer

Cervical cancer

Colon cancer

Colorectal cancer

Endometrial cancer

Kidney cancer

Leukemia

Liver cancer

Lymphoma

Ovarian cancer

Pancreatic cancer

Prostate cancer

Stomach cancer

Testicular cancer

Thyroid cancer

Vaginal cancer

Vulvar cancer

Antiviral & Anti-cancer,Acyclovir Tablet,Ondansetron Injection,Anti-Cancer Drug,Asparaginase Drug

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