Yunxu Bio exclusive M5C RNA methylation sequencing

Introduction to m5C RNA methylation

By analyzing the natural projects in recent years, we can find that the fund project of RNA methylation has grown exponentially in the past two years: especially from 5 in 2015 to 25 in 2017, the project growth is particularly significant. In January 2018, the literature on RNA methylation reached 25, and it can be said that the development of RNA methylation has reached the blowout stage, and many articles have been published in CNS-level journals.

Figure: RNA methylation over the years to publish article data

RNA methylation is an epigenetic modification of a new class of cognition, including 6-methyladenosine (m6A), 5-methylcytidine (m5C), 1-methyl Adenine (N1-methyladenosine, m1A) and the like. RNA methylation plays an important role in regulating gene expression, stability, and degradation. Among them, m5C RNA methylation is a new type of apparent transcriptomic modification, and it is also the latest international research hotspot, widely existed in non-coding RNA and partial mRNA. In order to systematically reveal the RNA methylation modification, Yunxu Biotech's exclusive m5C RNA methylation sequencing service can detect the gene m5C methylation modification distribution in a single base resolution within the whole transcriptome range.

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M5C RNA methylation literature analysis (impact factor: 11.9)

Here is a article about m5C methylation in the 2017 Genome Biology: The authors found that the m5C modification site in mouse embryonic stem cells is preferentially distributed near the mRNA start codon by m5C RNA methylation sequencing. It tends to be distributed in the 3'UTR region in mouse brain tissue. The m5C-modified RNA corresponding to the gene function GO annotation was analyzed by biosignal analysis. In addition, a combined analysis with CLIPdb revealed that approximately 29% of m5C RNA modification sites in mouse embryonic stem cells coincide with corresponding RBP (RNA-binding protein) binding sites, showing binding to RBP and functioning in specific transcripts. The potential of functionality.

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